Sevoflurane influenced inflammatory response on surgery patients with traumatic brain injury
10.3969/j.issn.1000-484X.2017.10.019
- VernacularTitle:七氟烷麻醉抑制急性创伤性颅脑损伤患者围手术期炎症介质的表达
- Author:
Ting Rui GUAN
1
;
Zhi Hong GAO
;
Yin Shuang LIANG
Author Information
1. 福建医科大学附属第二医院
- Keywords:
Traumatic brain injury;
Sevoflurane;
Inflammatory response;
Neuroprotection
- From:
Chinese Journal of Immunology
2017;33(10):1536-1538,1542
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of Sevoflurane on inflammatory response,neuro damage and the prognosis on surgery patients with traumatic brain injury ( TBI ) . Methods:From July 2015 to December 2016, 80 TBI patients undergoing neurosurgery were randomly divided into experimental group ( Sevoflurane treatment, n=40 ) and control group ( n=40 ) . The serum levels of TNF-α,IL-6,C-reactive protein ( CRP) and neuron specific enolase ( NSE) were tested with enzyme linked immunosorbent Assay (ELISA). GCS score,APACHEⅡ score and prognosises of the two groups were also compared. Results:Compared with control group,the serum levels of inflammatory related factors (CRP,TNF-α,IL-6) in the experimental group were significantly decreased in 1 hour of intraoperative,at the end of surgery and on 1st day after surgery respectively ( P<0. 05 or 0. 01 ) . Meanwhile, NSE protein expressions were significantly decreased(P<0. 05 or 0. 01). The experimental group received better prognosis compared to the control group,GCS scores[(10. 82±1. 40) vs (8. 29±1. 02),P=0. 03],APACHEⅡ scores[(14. 42±1. 97) vs (18. 03±2. 15),P=0. 02]on the 14th day. Conclusion:Sevoflurane treatment can effectively regulate the inflammatory response, reduce the neurons damage in surgery patients with TBI,possibly playing brain protection effect.
