Plasma Total Homocysteine Concentrations in Patients with Chronic Renal Failure.
- Author:
Yoon Goo KIM
1
;
Yoon Ha LEE
;
Kyu beck LEE
;
Se Ho CHANG
;
Dae Joong KIM
;
Ha Young OH
Author Information
1. Department of Internal Medicine, Sung Kyun Kwan University, College of Medicine, Samsung Seoul Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Homocysteine;
Renal failure;
Folate
- MeSH:
Chromatography, Liquid;
Creatinine;
Dialysis;
Fasting;
Folic Acid;
Homocysteine*;
Humans;
Hyperhomocysteinemia;
Kidney Failure, Chronic*;
Plasma*;
Renal Insufficiency;
Risk Factors;
Vascular Diseases
- From:Korean Journal of Nephrology
1997;16(4):682-687
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hyperhomocysteinemia, an independent risk factor of vascular disease, is common in patients with chronic renal failure(CRF) patients including dialysis patients. We measured fasting plasma concentrations of total homocysteine(tHcy) by high-performance liquid chromatography in 114 chronic renal patients and 37 healthy controls. The CRF patients were divided into four groups : chronic renal failure with serum creatinine >1.4mg/dl and creatinine clearance >10ml/min(CRF group, n=27), non-dialyzed ESRD patients with creatinine clearance <10ml/min(ESRD group, n=38), patients on maintenance hemodialysis(HD group, n=20) and patients on continuous ambulatory peritoneal dialysis(PD group, n=29). Mean(+/-SD) tHcy in each of CRF(14.2+/-5.6micromol/L), ESRD(21.6+/-14.1micromol/L), HD(21.0+/-9.2micromol/L) and PD(17.2+/-7.7micromol/L) group was significantly higher than that in controls(9.0+/-3.1micromol/L, P=0.001). In 87 ESRD, HD and PD patients, mean(SD) tHcy in 45 patients who received routine folate supplementation (1mg/day) was lower(17.5+/-8.3micromol/L) than that in 42 patients without supplementation(22.6+/-13.4micromol/ L, P=0.03), but was higher than that in controls (9.13.1micromol/L, P=0.001). In conclusion, hyperhomocysteinemia was present in patients with varying degree of chronic renal failure and increased in parallel with progression or renal failure.
