Effect of ultrasound guided percutaneous nephrostomy combined with Mailuoning on prognosis and TGF- beta 1 and alpha -SMA in patients with obstructive hydronephrosis
10.3969/j.issn.1005-1678.2017.10.049
- VernacularTitle:超声引导下经皮肾穿刺造瘘联合脉络宁对梗阻性肾积水患者预后及TGF-β1、α-SMA的影响分析
- Author:
min Li ZHU
1
;
Rong CHENG
;
juan Ya WANG
;
Li JI
;
Jing LI
Author Information
1. 陕西省核工业二一五医院 功能科
- Keywords:
upper urinary tract obstruction;
hydronephrosis;
ultrasound guided percutaneous nephrostomy;
transforming growth factor β 1;
alpha smooth actin;
Mailuoning injection
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(10):123-125
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of ultrasound guided percutaneous nephrostomy combined with Mailuoning injection on renal function, TGF- β 1 and α -SMA in patients with obstructive hydronephrosis. Methods 37 cases with obstructive hydronephrosis treated in our hospital from June 2014 to December 2016 were enrolled as the research object, all patients after admission were perfect relevant examination, after exclude contraindications underwent ultrasound-guided percutaneous nephrostomy combined with Mailuoning injection treatment. The operative time, the success rate of first puncture, the amount of bleeding during operation, hospitalization time, incidence of complications, preoperative and postoperative 3 d, 7 d renal function preoperative, postoperative, 7 d urine transforming growth factor β 1 (TGF- β 1) and alpha smooth muscle actin (α -SMA) were observed. Results The operation time was 52~93 minutes in 37 patients, the average operation time was (62.31±8.26) minutes; One puncture was successful in 37 cases, the success rate of one puncture was 100%. The intraoperative blood loss was 51 ~ 102 mL, the average amount of bleeding was (80.27±18.15) mL. The hospitalization time was 3 ~ 9 d, the average time was (6.12±1.97)d.In 37 cases, three cases were blocked by ostomy, the incidence rate was 8.11 %; The fistula was removed in one cases, the incidence rate was 2.70%; seven cases with dermatitis around the fistula, the incidence rate was 18.92%. At 3 d after surgery, BUN and Cr were significantly decreased than before operation (P<0.05). At 7 d after surgery, BUN and Cr were significantly decreased compared with preoperative and postoperative 3 d (P<0.05). The levels of TGF-β1 and α-SMA in patients were significantly lower than those before operation at 7 days after operation (P<0.05). Conclusion Ultrasound guided percutaneous nephrostomy combined with Mailuoning injection in the treatment of obstructive hydronephrosis can timely drainage of urine, improve renal function, avoid ipsilateral renal interstitial fibrosis. The utility model has the advantages of high rate of success and safe operation.
