Progress in the study of the formation and function characteristics of stress granules and its correlation with diseases
- VernacularTitle:应激颗粒的形成和功能特点及其与疾病的相关性研究进展
- Author:
ying Feng LIANG
1
;
Wei HAN
Author Information
1. 哈尔滨医科大学附属第一医院 心内科
- Keywords:
stress response;
stress granules;
ribosome;
dynamic state;
disease
- From:
Basic & Clinical Medicine
2017;37(10):1461-1465
- CountryChina
- Language:Chinese
-
Abstract:
When eukaryotic cells face various environment stimulation,eukaryotic cells form some dense granules in hyalomitome,that are stress granules(SGs).They have antioxidant and inhibit apoptosis. Interaction between mRNA-binding proteins promotes stress granule formation. Assembly and disassembly of stress granules are modulated by va-rious post-translational modifications as well as numerous ATP-dependent RNP or protein remodeling complexes.Stress granules have the ability of liquidity,and energy input is required to maintain their dynamic state.Stress granule for-mation can regulate the process of stress reaction,virus infection and the signal transduction.The formation of constant and the abnormal stress granules result in neurodegenerative diseases and certain types of cancer.
