Down-regulated expression of duodenal tight junction proteins in model rats with Parkinson's disease
- VernacularTitle:帕金森病模型大鼠十二指肠黏膜紧密连接蛋白表达下调
- Author:
ni Dong ZHANG
1
;
an Yi WANG
;
wen Guang LI
;
ming Li YAN
;
yan Xiao FENG
;
xia Jin ZHU
Author Information
1. 首都医科大学 基础医学院
- Keywords:
PD model rats;
duodenum;
claudin-14;
occludin;
ZO-1
- From:
Basic & Clinical Medicine
2017;37(10):1359-1362
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the alterations of tight junction proteins in duodenal mucosa from 6-hydroxydopamine (6-OHDA)-induced Parkinson's disease(PD) model. Methods Rats were subjected with 6-OHDA in bilateral substantia nigra (SN) as PD model. The location and quantitative detecting techniques inclu-ding immunohisto- chemistry and western blotting were used to determine the expressions and alterations of tight junction proteins (claudin-1, occludin, ZO-1). Results Claudin-1, occludin and ZO-1 were highly expressed in the duodenal mucosa of PD models, where the expressions of occluding (P<0.001) and ZO-1 (P<0.001) were much lower, while the expression of claudin-1 had no alteration. Conclusions The down-regulated expres-sion of occludin and ZO-1 was detected in duodenal mucosa of PD models, which might be related to duodenal ulcer in PD.
