Relationship Between Plasma suPAR Level and Acute Coronary Syndrome With its Influencing Factors
10.3969/j.issn.1000-3614.2017.10.009
- VernacularTitle:血浆可溶性尿激酶型纤溶酶原激活物受体水平与急性冠状动脉综合征的相关性及其影响因素的研究
- Author:
lei Jing NIU
1
;
Yu PENG
;
Ming BAI
;
yu Xing GAO
;
li Hong MA
;
liang Chen PAN
;
zhi Ying JIANG
;
Zheng ZHANG
Author Information
1. 兰州大学第一临床医学院兰州大学第一医院 心脏中心
- Keywords:
Acute coronary syndrome;
Soluble urokinase plasminogen activator receptor;
C- reaction protein
- From:
Chinese Circulation Journal
2017;32(10):970-974
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the relationship between plasma level of soluble urokinase plasminogen activator receptor (suPAR) and the severity of acute coronary syndrome (ACS) with its influence factors. Methods: A total of 321 consecutive patients with chest pain admitted in our hospital from 2015-03 to 2016-09 were studied. According to clinical presentation, laboratory test and coronary angiography (CAG), the patients were divided into 2 groups: ACS group, n=228 and Control group, the patients with normal coronary artery, n=93. Plasma levels of suPAR and high sensitive C reaction protein (hs-CRP) were measured by ELISA and compared between 2 groups. Results: The levels of plasma suPAR in ACS patients were significantly higher than those in the control group (OR= 0.104, 95％ CI: 0.048-0.223, P<0.01). In ACS group, the plasma suPAR level gradually increased with the increase of Gensini score, The sensitivity and specificity of the levels of suPAR were determined by ROC curve. The values of ACS were predicted to be 1.8 μg / L, the sensitivity was 0.732 and the specificity was 0.710. Multiple linear regression analysis showed that smoking, Gensini score and uric acid were the main factors affecting plasma suPAR levels. Conclusion: Elevated plasma suPAR level has been related to the severity of coronary stenosis in ACS patients, such relationship is superior to hs-CRP; suPAR might be worked as a new biomarker for predicting coronary stenosis and risk stratification in ACS patients.
