Significance and prognosis evaluation of monitoring plasma B-type natriuretic peptide and cardiac troponin I in patients with sepsis
10.3760/cma.j.issn.1008-6315.2017.10.009
- VernacularTitle:监测血浆B型尿钠肽和肌钙蛋白I在脓毒症患者中的意义和预后评估
- Author:
Lei DING
1
;
Ning′an PENG
Author Information
1. 100054,北京市健宫医院重症医学科
- Keywords:
Sepsis;
B-type natriuretic peptide;
Troponin I;
Cardiac insufficiency
- From:Clinical Medicine of China
2017;33(10):900-903
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the significance and prognostic evaluation of plasma B-type natriuretic peptide(BNP)and troponin(cTnI)in patients with sepsis.Methods A retrospective analysis was performed on the clinical data of ninety cases of diagnosed septic patients in Beijing Jiangong Hospital from October 2015 to October 2016,the patients were divided into the survival group and the death group.According to the cardiac function,the patients were assigned into the normal heart function group and the heart failure group,and then the cardiac insufficiency patients were divided into the cardiac insufficiency-dead group and cardiac insufficiency-survival group,The plasma levels of BNP and cTnI in each group were detected,and the ROC curve was used to evaluate the influence of BNP,cTnI on patients' prognosis.Results According to cardiac function grouping,BNP and cTnI in the cardiac insufficiency group were significantly higher than those in the normal cardiac function group(BNP:6980(5600,9850)ng/L vs.2500(1250,5640)ng/L〕; cTnI: 0.82 (0.52,1.22)μg/L)vs.0.52(0.25,0.66)μg/L),the differences were statistically significant(P<0.05);BNP in the cardiac insufficiency-dead group(8540(5680,13500)ng/L)was significantly higher than that in the cardiac insufficiency-survival group(5200(3570,8080)ng/L),the difference was statistically significant (P<0.05); There was no significant difference in cTnI between the cardiac insufficiency-dead group and the cardiac insufficiency-survival group(P>0.05);According to the prognosis,BNP and cTnI in the cardiac insufficiency-dead group were all significantly higher than those in the cardiac insufficiency-survival group〔BNP:7760(4755,11820)ng/L vs.2058(1200,4711)ng/L; cTnI:〔0.75(0.58,1.46)μg/L〕 vs.0.33(0.22, 0.61)μg/L〕,the differences were statistically significant(P<0.05).Conclusion The increase of BNP and cTnI in plasma may indicate a worse prognosis for patients.The monitoring of BNP and cTnI in plasma is helpful for early detection of cardiac dysfunction in patients with sepsis.
