Validation of G-protein beta-3 subunit gene C825T polymorphism as predictor of obesogenic epidemics in overweight/obese Korean children.
10.4163/jnh.2016.49.4.223
- Author:
Yunkyoung LEE
1
;
Seong min PARK
;
Myoungsook LEE
Author Information
1. Department of Food Science and Nutrition, Jeju National University, Jeju 63243, Korea.
- Publication Type:Original Article
- Keywords:
children obesity;
gender;
GNB3 C825T polymorphism;
obesogenic
- MeSH:
Alleles;
Anthropometry;
Blood Pressure;
Child*;
Chronic Disease;
Cross-Sectional Studies;
Energy Intake;
Fasting;
Female;
Gene Frequency;
GTP-Binding Proteins*;
Humans;
Korea;
Risk Factors;
Seoul;
Triglycerides;
Waist Circumference
- From:Journal of Nutrition and Health
2016;49(4):223-232
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: We investigated the potential interaction between the G-protein beta-3 subunit gene (GNB3) C825T polymorphism, a risk factor for chronic disease in various ethnicities, and obesogenic environments in overweight/obese Korean children. METHODS: The present study was conducted as a cross-sectional study using measures of anthropometry, blood pressure (BP), and fasting blood samples as well as 3-day food records. Subjects were recruited from seven elementary schools in an urban district in Seoul, South Korea, between 2007 and 2008. A total of 1,260 children aged 8-9 years were recruited in the study, including 633 boys (50.3%) and 627 girls (49.7%). RESULTS: The allele frequencies of the GNB3 polymorphism were C allele = 49.7% and T allele = 50.3% in subjects. In general, boys with T allele had higher BMI, systolic BP (SBP), and triglycerides, although their energy intake was not significantly different from boys with C allele. In contrast to boys, girls with T allele had lower BMI but higher SBP and energy intake than those with C allele. The girls with T allele had a significantly lower BMI and waist circumference in both the normal weight group and obese group (OB). T allele carriers in both genders had significantly higher TC than C allele carriers in the OB group. At last, girls with T allele in OB appeared to have significantly lower HOMA-IR than those with C allele. CONCLUSION: Unlike higher risk for negative health outcomes by the GNB3 polymorphism in various ethnicities, GNB3 polymorphism did not influence obesogenic environments in overweight/obese Korean children.
