Influence of intensive heart rate control on inflammatory factor and cardiac function in patients with chronic heart failure
10.3969/j.issn.1006-5725.2017.19.021
- VernacularTitle:心率控制对慢性心力衰竭患者炎症因子及心功能的影响
- Author:
Ming LU
1
;
Qingyuan JIANG
;
Chunlan LIU
;
Yingying LIU
;
Jia LING
;
Lihong KAN
;
Xiaohua ZHUANG
;
Zhenrong CAI
Author Information
1. 复旦大学附属浦东医院心血管内科
- Keywords:
heart rate;
inflammatory factor;
chronic heart failure;
brain natriuretic peptide;
car-diac function
- From:
The Journal of Practical Medicine
2017;33(19):3235-3239
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of intensive heart rate control on inflammatory factor and cardiac function in patients with chronic heart failure. Methods From January 2015 to December 2015 ,a total of 120 CHF patients in New York Heart Association(NYHA)functional classes Ⅱ to Ⅳ were enrolled and randomized into treatment group(n=60)and control group(n=60). All the patients were in stable situation af-ter conventional drug treatment. The patients in treatment group underwent intensive heart rate control for target HR (55~60 beats/min)through adjusting the dose of metoprolol sustained-release tablets. The concentration of C-reac-tion protein(CRP),interleukin-1β(IL-1β),interleukin-6(IL-6)and tumor necrosis factorα(TNF-α)were de-tected before and after 6-month treatment. The resting heart rate and the concentration of brain natriuretic peptide (BNP),left ventricular ejection fracetion(LVEF),left ventricular end diastolic diameter(LVEDD)and left ven-tricular end systolic dimension(LVEDD)were measured at the start and 6-months after treatment. Results After 6-month treatment,the resting heart rate of the patients in the treatment group decreased significantly compared with that of the control group(P<0.001). Inflammatory factors(CRP,IL-1β,IL-6 and TNF-α)levels decreased significantly compared with that of control group (P < 0.05). The echocardiography parameters (LVEDD and LVESD)and the concentration of BNP of the patients in the treatment group decreased significantly(P < 0.05), LVEF of treatment group increased significantly(P < 0.05). Conclusion Intensive heart rate control in patients with chronic heart failure can significantly reduce Inflammatory factor levels and improve the cardiac function.
