Therapeutic effect and white matter integrity of low frequency repetitive transcranial magnetic stimulation and the modified electric convulsive therapy in patients with schizophrenia
10.3969/j.issn.1006-5725.2017.19.023
- VernacularTitle:低频重复经颅磁刺激与无抽搐电休克治疗精神分裂症患者的疗效及白质完整性分析
- Author:
Li PU
1
;
Bo XIANG
;
mei Xue LIANG
;
Kezhi LIU
;
Lishi LUO
Author Information
1. 西南医科大学附属医院精神科
- Keywords:
schizophrenia;
multiple energy computed tomography;
repetitive transcranial magnetic stimulation;
white matter
- From:
The Journal of Practical Medicine
2017;33(19):3243-3247
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and white matter integrity of low frequency repetitive transcranial magnetic stimulation (rTMS) and the modified electroconvulsive therapy (MECT) in patients with schizophrenia. Methods From May 2015 to October 2016,120 cases with schizophrenia were randomly enrolled into the MECT group and of the rTMS group. Patients in the MECT group were treated with the modified electric convulsive therapy for 8 times ,while patients in the rTMS group were treated with the repetitive transcranial magnetic stimulation for 12 times. PANSS were used to evalue the clinical effects. Repeatable battery for the assess-ment of neuropsychological status was used to assess the cognitive function. Treatment emergent side-effect scale was used to assess the adverse effects. Brain fractional anisotropy was used to assess white matter integrity. Results After treatment,the PANSS scores were significantly lowered,however,the RBANS scores were signifi-cantly higher in the MECT group and rTMS group than those before treatment ,with significant differences (P <0.05). No significant differences for the PANSS scores and the RBANS scores were observed between the two groups before and after treatment. There was no significant difference for the TESS scores between the two groups before treatment(P > 0.05). After treatment,the TESS scores in the MECT group were significantly higher than those in the rTMS group(P < 0.05). After treatment,the FA values of left anterior cingulate gyrus,left posterior cingulate gyrus ,left prefrontal cortex and genu of corpus callosum for both MECT group and rTMS group were significantly increased (P < 0.05 ,respectively). Compared with the MECT group ,the FA value significantly increased in the rTMS group after treatment (P < 0.05). Conclusions Both MECT and rTMS have significant clinical efficacies and can improve the cognitive function of schizophrenics. rTMS is more safe than MECT ,with a stronger effect on preventing the integrity of white matter than MECT.
