Observation of medium and long term efficacy of hemodialysis combined with hemoperfusion on the endo-thelial function in patients with maintance hemodialysis
10.3969/j.issn.1006-5725.2017.20.027
- VernacularTitle:中长期血液透析联合血液灌流对维持性血液透析患者血管内皮功能的影响
- Author:
Xiaolei LI
1
;
Yaozhong KONG
;
Guanqing XIAO
;
Wei SHEN
;
Youyuan CHEN
;
Dao LI
;
Aizhen HOU
;
Xuefang HUANG
;
Yan LI
Author Information
1. 中山大学附属佛山医院肾内科
- Keywords:
hemoperfusion;
endothelial cell;
advanced glycation end products;
homocysteine
- From:
The Journal of Practical Medicine
2017;33(20):3437-3440
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the medium and long term efficacy of hemodialysis combined with hemo-perfusion on the endothelial function in patients with maintance hemodialysis(MHD). Methods 60 stable MHD patients were enrolled in the research and randomly divided into 2 group. The observation group received hemodialy-is combined blood perfusion,and the control group received pure hemodialysis therapy. Blood was collected before and after treatment for 6 months for detection of serum C-reactive protein (CRP),hemoglobin (HB),albumin (ALB),advanced glycation end products(AGEs),homocysteine(Hcy)and intercellular cell adhesion molecule (ICAM). Results Plasma hs-CRP,AGEs,Hcy and ICAM decreased gradually after the treatment for 6 months. Compared with the indexes before treatment ,serum HGB and ALB increased significantly after the treatment for 6 months(P < 0.05). Conclusions Hemodialysis combined with hemoperfusion with an appropriate frequency and in a medium or long period is a safe ,convenient,and effective approach for MHD patients to pretect the endotheli-al function.
