Research progress of mTOR signaling pathway and synovial sarcoma
10.11904/j.issn.1002-3070.2017.05.018
- VernacularTitle:mTOR信号通路与滑膜肉瘤研究进展
- Author:
Yishu LIU
1
Author Information
1. 哈尔滨医科大学附属肿瘤医院
- Keywords:
mTOR;
Synovial sarcoma;
Tumor
- From:
Practical Oncology Journal
2017;31(5):477-480
- CountryChina
- Language:Chinese
-
Abstract:
The mammalian target of rapamycin(mTOR)is a ser/threonine protein kinase,which belongs to the family of phosphatidylinositol trioxolase-related kinases.By influencing key factors such as AKT,4EBP1 and S6K1,play an important role in the development of tumors.Synovial sarcoma(SS)is a highly malignant soft tissue sarcoma,early surgery and chemotherapy is the mainstream of the current treatment.However,late survival rate is still not ideal.In order to provide A new direction for treatment of synovial sarcoma is provided through the reseach of signaling pathway conduction.In this paper,recent studies on mTOR and synovial sarcoma are re-viewed.
