Current status of quantitative multimodality MRI features and IDH gene mutation in gliomas
10.13929/j.1003-3289.201703090
- VernacularTitle:脑胶质瘤IDH基因突变与定量多模态MRI研究进展
- Author:
Dongdong MEI
1
;
Jingshan GONG
;
Yongguang LIU
;
Xia FENG
Author Information
1. 暨南大学第二临床医学院深圳市人民医院放射科
- Keywords:
Isocitrate dehydrogenase;
Mutation;
Gliomas;
Magnetic resonance imaging
- From:Chinese Journal of Medical Imaging Technology
2017;33(10):1550-1553
- CountryChina
- Language:Chinese
-
Abstract:
The mutation of isocitrate dehydrogenase (IDH) gene is associated with gliomagenesis.It has also significant positive effects on survival and chemosensitivity in comparison with IDH wild-type glioma.Being an important energetic metabolism enzyme,mutation of IDH results in changes of microstructures and metabolism.Quantitative multimodality MR imaging has ability to obtain imaging biomarkers about microstructural,physiologic and functional information,which demonstrates the promises to assess IDH gene status in vivo.The progresses of association between quantitative multimodality MRI features and IDH genesmutations in glioma were reviewed in this paper.
