Clinical Value of Combination Detection of Inhibin A, Progesterone and Fetal Fibronectin in Predicting the Outcome of Threatened Abortion
10.11969/j.issn.1673-548X.2017.09.037
- VernacularTitle:抑制素A、孕酮和胎儿纤维连接蛋白联合检测在预测先兆流产结局中的临床价值研究
- Author:
Shufen PAN
1
;
Jieli WU
;
Jieqiang LÜ
Author Information
1. 325000,温州医科大学定理临床学院、温州市中心医院妇产科
- Keywords:
Inhibin A;
Progesterone;
Fetal fibronectin;
Threatened abortion
- From:
Journal of Medical Research
2017;46(9):142-145
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical value of combination dection of inhibin A,progesterone and fetal fibronectin in predicting the outcome of threatened abortion.Methods One hundred and seventy patient with symptoms of threatened abortion were selected as the object of this study.After miscarriage treatment,75 patients continued the pregnancy as the threatened abortion group and 45 patients miscarriage after miscarriage treatment as the abortion group,another 50 normal pregnant women at same period in our hospital were as the control group.Inhibin A,progesterone and fetal fibronectin were detected and compared between the three groups.Results The inhibin A and progesterone levels increased in turn from abortion group,threatened abortion group to normal pregnancy group.fFN positive rates were lower in turn.The difference were statistically significant (P ＜ 0.05).The area under the ROC curve (AUC) of inhibin A,and progesterone levels fFN positive rate for prediction of threatened abortion were 0.899,0.866,0.785,while the AUC of the combine that three index was 0.944.The sensitivity of the combined detection was 92.04％,the specificity was 89.17％,accuracy was 87.95％,positive predictive value was 98.45％,negative predictive value was 89.38％,and Youden index was 0.812.Conclusion Combined detection of inhibin A,progesterone and fetal fibronectin in predicting the outcomes of threatened abortion of pregnant women have a better predictive value than single index,it can enhance the accuracy,specificity and accuracy of forecasts.
