Clinical course and prognosis of hemodynamically significant congenital heart defects in very low birth weight infants.
10.3345/kjp.2009.52.4.481
- Author:
Hye Soo YOO
1
;
Ji Eun KIM
;
Soo Kyoung PARK
;
Hyun Ju SEO
;
Yoo Jin JEONG
;
Seo Heui CHIO
;
Soo In JEONG
;
Sung Hoon KIM
;
Ji Hyuk YANG
;
June HUH
;
Yun Sil CHANG
;
Tae Gook JUN
;
I Seok KANG
;
Won Soon PARK
;
Pyo Won PARK
;
Heung Jae LEE
Author Information
1. Department of pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Infant;
Very Low Birth Weight;
Congenital Heart Defects;
Congenital Abnormalities;
Chromosome Disorders
- MeSH:
Birth Weight;
Bronchopulmonary Dysplasia;
Chromosome Disorders;
Congenital Abnormalities;
Early Intervention (Education);
Enterocolitis, Necrotizing;
Fetal Growth Retardation;
Gestational Age;
Heart Defects, Congenital;
Heart Septal Defects, Ventricular;
Hemorrhage;
Humans;
Incidence;
Infant;
Infant, Newborn;
Infant, Very Low Birth Weight;
Intensive Care, Neonatal;
Leukomalacia, Periventricular;
Medical Records;
Prognosis;
Retrospective Studies;
Thoracic Surgery
- From:Korean Journal of Pediatrics
2009;52(4):481-487
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study investigated the clinical course and prognostic factor of very low birth weight infants (VLBWI) with hemodynamically significant congenital heart defects (CHDs). METHODS: Medical records of 1,098 VLBWI with birth weight <1,500 g who had been admitted to the neonatal intensive care unit of Samsung Medical Center from October 1994 to December 2007 were reviewed retrospectively. The data for these patients with hemodynamically significant CHD (n=33) were compared with those without CHD (n=1,065). RESULTS: The incidence of CHD was 3.0% (33 patients) 7 patients (21%) had CHD combined with the congenital abnormalities or chromosomal disorders. The most common CHD was a ventricular septal defect. The incidence of intrauterine growth retardation was higher in patients with CHD than in patients without CHD (34% vs. 20%), but there were no significant differences in gestational age, birth weight, respiratory distress syndrome, bronchopulmonary dysplasia, necrotizing enterocolitis, severe intraventricular hemorrhage (> or =Gr III), and periventricular leukomalacia. Cardiac surgery was performed on 13 patients (39%). Nine patients received staged operations, and 10 patients received early intervention. The overall mortality in patients who had CHD was higher than in the patients who did not have CHD (27% vs. 16%). In patients with CHD, congenital abnormalities or chromosomal disorders were more important factors for increased mortality (86% vs. 11%) than the degree of complexity of CHD (19% vs. 42%). CONCLUSION: The most important prognostic factors of VLBWI with CHD are the associated congenital abnormalities or chromosomal disorders.
