Impact of maternal antibodies on protective efficacy of rotavirus vaccine:a review
10.3760/cma.j.issn.0254-5101.2017.09.010
- VernacularTitle:母源抗体对轮状病毒疫苗保护性的影响
- Author:
Guoxing LUO
1
;
Tingdong LI
;
Shengxiang GE
Author Information
1. 361005 厦门大学国家传染病诊断试剂与疫苗工程技术研究中心,分子疫苗学与分子诊断学国家重点实验室,厦门大学生命科学学院
- Keywords:
Rotavirus;
Maternal antibody;
Milk antibody;
Vaccine;
Immune response
- From:
Chinese Journal of Microbiology and Immunology
2017;37(9):703-708
- CountryChina
- Language:Chinese
-
Abstract:
Rotavirus is one of the most common causes of gastroenteritis among children under five years of age worldwide. Most children are infected with rotavirus in their early childhood. Currently, no ef-fective treatment is available for diarrhea caused by rotavirus infection, and vaccination is the most effective way to prevent rotavirus infection. With the introduction of rotavirus vaccines, the morbidity and mortality of severe diarrhea in children caused by rotavirus infection are declined significantly, but these rotavirus vac-cines have significantly lower efficacy in developing countries in Africa and some countries in Asia where the mortality of rotavirus-related diseases is high than in developed countries. High titers of maternal antibodies may be one of the reasons why the efficacy of rotavirus vaccines is low in these countries. Extensive studies have been conducted on the relationship between neonatal response to rotavirus vaccine immunization and ro-tavirus-specific antibodies in the mother′s milk and serum in recent years. However, results of some studies are in conflict. In this review, we summarize the relationship between maternal antibodies and the immune responses after vaccination with rotavirus vaccines in order to provide basis for improving the efficacy of rota-virus vaccines in low-income countries.
