Advances in novel linezolid resistance gene optrA

VernacularTitle:利奈唑胺耐药新基因optrA研究进展
Author: Lanqing CUI ¹ ; Yuan LYU
Author Information

1. 100034,北京大学第一医院临床药理研究所
Keywords: Linezolid; Resistance; optrA; Epidemiology; Molecular transmission mechanism
From: Chinese Journal of Microbiology and Immunology 2017;37(9):709-711
CountryChina
Language:Chinese
Abstract: optrA, a transferrable linezolid resistance gene, was identified in a clinical strain of En-terococcus faecalis isolated in China in 2015. This gene is 1968 bp in length, encoding 655 amino acids. And the sequence of these amino acids shares high homology with the amino acid sequence of ABC transport-er, resulting in resistance to oxazolidinones ( linezolid and tedizolid) and phenicols ( florfenicol and chloram-phenicol) . Linezolid is an important oxazolidinone antibiotic used in the treatment of refractory infections such as infections caused by methicillin-resistant Staphylococcus aureus. Therefore, the appearance and prev-alence of optrA gene have drawn worldwide attention. In this review, we focus on the discovery, epidemiolo-gy and molecular transmission mechanism of optrA gene.