Animal models of dengue virus infection
10.3760/cma.j.issn.0254-5101.2017.09.012
- VernacularTitle:登革病毒动物模型的研究进展
- Author:
Yanping ZHOU
1
;
Xiaoqi CHEN
;
Shuo SHEN
Author Information
1. 30207,武汉生物制品研究所有限责任公司病毒性疫苗研究一室
- Keywords:
Animal model;
Dengue virus;
Pathogenesis;
Antiviral drug;
Vaccine
- From:
Chinese Journal of Microbiology and Immunology
2017;37(9):712-720
- CountryChina
- Language:Chinese
-
Abstract:
Dengue virus ( DENV) threatens the lives of hundreds of millions of people every year. Animal model is an effective tool for virus pathogenesis research and vaccine evaluation. At present, the de-velopment of animal models of DENV infection and disease has been challenging, as epidemic DENV does not naturally infect non-human species. Animal models of dengue virus infection are mainly non-human pri-mate ( NHP) model and mouse model. NHPs have been used to study dengue infection and candidate vac-cines because they can sustain viral replication in relevant cell types and develop a robust immune response, but they do not develop overt disease. However, NHP models are not suitable for early preclinical studies be-cause the cost of using these animals is high. In contrast, mouse models that are established mainly by using wild-type and immunodeficient mice can be more economical for preclinical evaluation of dengue vaccines. Overall, every model has its advantages and disadvantages and is differentially suited for studies of dengue pathogenesis and immunopathogenesis and/or preclinical testing of antiviral drugs.
