Mechanism of tumor tolerance mediated by immune microenvironment and its targeted therapy
10.3760/cma.j.issn.1673-422X.2017.08.009
- VernacularTitle:免疫微环境介导的肿瘤耐受机制及其靶向治疗
- Author:
Yuanyuan XU
1
;
Li ZHANG
;
Liangkun JIN
Author Information
1. 650000,昆明市第一人民医院肿瘤内科
- Keywords:
Neoplasms;
Therapy;
Immune microenvironment
- From:
Journal of International Oncology
2017;44(8):594-596
- CountryChina
- Language:Chinese
-
Abstract:
Immune cells interact with their secreted cytokines forming immune microenvironment that plays an important role in the treatment resistance.Immune microenvironment induces tumor tolerance by reducing the anti-apoptotic pathway,mediating immune tolerance,inducing epithelial mesenchymal transformation and the formation of tumor stem cells,reducing the curative effect.Tumor immunotherapy has become a hot topic in the field of tumor therapy research.
