Clinical value of Xpert MTB/RIF in the early diagnosis of tuberculous meningitis
10.3969/j.issn.1673-4130.2017.19.002
- VernacularTitle:Xpert MTB/RIF在早期诊断结核性脑膜炎中的临床应用价值
- Author:
Rui LIU
1
;
Huan ZHANG
;
Suli CHEN
;
Weihong LI
;
Xiaoguang ZHANG
;
Yong WANG
;
Hejuan AN
;
Hui LIU
Author Information
1. 河北省胸科医院结核三科
- Keywords:
Xpert M TB/RIF;
tuberculous meningitis;
diagnosis;
rifampin;
drug resistant
- From:
International Journal of Laboratory Medicine
2017;38(19):2660-2662
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of Xpert M TB/RIF in the early diagnosis of tuberculous meningitis (TBM ) .Methods Totally 130 patients with central nervous system infection in our hospital from February 2015 to December 2016 were divided into two groups ,65 cases of TBM patients as the TBM group ,65 cases of non TBM patients as the non TBM group . The CSF samples of all patients were respectively detected by acid fast staining ,Roche solid culture and Xpert MTB/RIF assay .The test results were compared .Results With clinical diagnosis as the gold standard ,the sensitivity of Xpert MTB/RIF to detection of TBM was 43 .08% and specificity was 100 .00% .The sensitivity of solid culture to detection of TBM was 58 .46% and specificity was 98 .46% .The sensitivity of acid fast staining to detection of TBM was 9 .23% and specificity was 100 .00% .Based on the re-sults of drug sensitivity test of traditional proportional method ,the sensitivity of Xpert M TB/RIF to detection of rifampin resistance was 88 .89% and specificity was 98 .35% .Conclusion Xpert M TB/RIF is a new diagnostic technique for detecting TBM and ri-fampin resistance in patients .It has the advantages of rapid ,direct ,reliable and high specificity and is worthy of clinical application .
