Genetic characteristics of rubella viruses in Chongqing from 2011 to 2016
10.3969/j.issn.1673-4130.2017.19.004
- VernacularTitle:重庆市2011-2016年风疹病毒基因特征分析
- Author:
Hua ZHAO
1
;
Jingyao PENG
;
Chunfang ZHAO
;
Zhen ZHU
;
Hua LING
;
Min ZHANG
;
Wei HUANG
Author Information
1. 重庆市疾病预防控制中心
- Keywords:
rubella virus;
genotype;
sequence analysis
- From:
International Journal of Laboratory Medicine
2017;38(19):2666-2668
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify and analyze the genetic characterization of rubella viruses isolated in Chongqing from 2011 to 2016 ,so as to provide molecular epidemiological evidence for rubella prevention and control .Methods Virus samples isolated from Chongqing city from 2011 to 2016 for detection of rubella virus nucleic acid were collected ,and their genotypes were identified by sequence analysis .Phylogenetic tree construction and genetic distance analysis were carried out among rubella virus types ,reference strains and other provinces and cities in GenBank .Results The predominant genotype from 2011 to 2013 was 1E (94/103) ,from 2014 to 2016 was 2B (50/56) .Only one strain of genotype 2A was found in 2014 .The homology of 1E genotype between Chongqing and other provinces was 97 .63% to 99 .73% ,with an average of 98 .90% .The homology of 2B genotype between Chongqing and other provinces was 95 .77% to 99 .73% ,with an average of 98 .30% .The Chongqing rubella viruses strains didn′t isolate form oth-er province strains of China in phylogenetic tree .Conclusion The predominant genotype 1E of rubella virus in Chongqing was grad-ually replaced by 2B in recent years .The rubella virus genotypes in Chongqing are changing ,and the dominant strains are in a state of coevolution with other provinces and cities .
