Progress of drug resistance mechanisms in acute promyelocytic leukemia
10.3760/cma.j.issn.1009-9921.2017.10.016
- VernacularTitle:急性早幼粒细胞白血病耐药机制的研究进展
- Author:
Xiaodan ZHOU
1
Author Information
1. 221002,徐州医科大学血液病研究所 徐州医科大学附属医院血液科
- Keywords:
Leukemia;
promyelocytic;
acute;
Drug resistance;
neoplasm;
Tretinoin
- From:
Journal of Leukemia & Lymphoma
2017;26(10):637-640
- CountryChina
- Language:Chinese
-
Abstract:
Since all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3) have become front-line drugs in treatment of acute promyelocytic leukemia (APL), cure rates of APL patients have improved dramatically. However, resistance to ATRA and/or As2O3has been a critical problem which has hampered the effect of treatment. In this review, some emerging mechanisms of resistance to ATRA and/or As2O3in recent years, such as genetic mutations, disorders of cellular signal transduction, disorders of chromatin remodeling complex, abnormal regulation of cell apoptosis, and micro-environment mediated drug resistance are summarized.
