Protective effect of rosuvastatin on acute kidney injury in the patients after coronary artery bypass grafting
10.3760/cma.j.issn.1671-0282.2017.09.008
- VernacularTitle:瑞舒伐他汀对冠状动脉旁路移植术患者术后急性肾损伤的影响
- Author:
Zhengrong LI
1
;
Zonglin ZHANG
;
Xiangfeng LIU
;
Junsheng LI
;
Xiuhui ZHANG
;
Zengcheng SHI
;
Zhihong OU
Author Information
1. 山东大学附属临沂市人民医院药学部
- Keywords:
Rosuvastatin;
Coronary artery bypass grafting;
Perioperative;
Acute kidney injury;
Renal function
- From:
Chinese Journal of Emergency Medicine
2017;26(9):1015-1019
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prevention of acute kidney injury (AKI) by earlier application of rosuvastatin in patients after coronary artery bypass grafting (CABG).Methods A total of 200 patients with CABG were enrolled from May 2013 to April 2017.According to whether rosuvastatin were used routinely before operation or not,all patients were divided into the trial group (n =136) and the control group (n =64).Demographics,and clinical data were collected before and after CABG.The renal function markers including blood urea nitrogen (BUN),serum creatinine (sCr),endogenous creatinine clearance rate (GFR),emergence of AKI of two groups were documented and compared.Enumeration data were analyzed with x2 test,measurement data were analyzed with t test,and P ＜ 0.05 was considered to be significant.Results There were no differences in sCr (t =-1.156,P ＞ 0.05) but differences in BUN and eGFR (t =-2.915,3.690,respectively,P ＜ 0.05) before operation between two groups.After operation,the BUN was decreased (t =2.486,P ＜ 0.05) compared with that of pre-operation in the trial group,but there were no significant difference in sCr and eGFR (t =-1.877,-0.752,respectively,P ＞0.05).The BUN and sCr were increased (t =-3.792,-5.027,respectively,P ＜ 0.05) after operation compared with that of pre-operation in the control group,while the eGFR was decreased (t =5.540,P ＜0.05).Compared with the control group,BUN,sCr and the incidence of AKI were significantly decreased in the trial group (t/x2 =5.759,4.196,15.506,respectively,P ＜0.05),while the eGFR was increased (t =-6.215,P ＜ 0.05).Conclusions Earlier application of rosuvastatin before CABG can effectively protect renal function and reduce the incidence of AKI.
