Advances in the role of autophagy in acute pancreatitis
10.3760/cma.j.issn.2095-4352.2017.10.019
- VernacularTitle:自噬在急性胰腺炎中的研究进展
- Author:
He XIA
1
;
Liang ZHAO
;
Weixing WANG
Author Information
1. 武汉大学人民医院普通外科
- Keywords:
Autophagy;
Acute pancreatitis;
Pancreatic enzyme activation;
Mechanism
- From:Chinese Critical Care Medicine
2017;29(10):950-953
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a self-protect cellular mechanism by which the unneeded cellular structure or impaired protein are targeted to degeneration. Acute pancreatitis (AP) is associated with autophagy tightly. This article is aimed to mainly elaborate the phenomenon that AP can be triggered by impaired autophagy and the mechanism of AP exacerbation by damaged autophagy. In AP, the reasons of impaired autophagy is dysfunction of cathepsins and lysosome associated membrane protein, which present as vacuoles accumulation in acinar cells and combination disorder of autophagolysosome, finally to activation of trypsin. By the relocation of high mobility group box 1 (HMGB1) and promotion of mitochondrial permeability transition (MPT), impaired autophagy aggravates AP. Understanding the above mechanism has certain significance to the prevention and treatment of AP.
