Changes in distribution and antimicrobial resistance of pathogens causing bloodstream infection in 2012-2015
10.3969/j.issn.1671-9638.2017.10.009
- VernacularTitle:2012—2015年医院血流感染病原菌分布及耐药性变迁
- Author:
fei Teng XU
1
;
wu Zhi LIU
;
ling Feng JIN
Author Information
1. 兰州大学第一医院
- Keywords:
bloodstream infection;
pathogen;
drug resistance,microbial
- From:
Chinese Journal of Infection Control
2017;16(10):936-940
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes in distribution and antimicrobial resistance of pathogens causing bloodstream infection in a hospital in 2012-2015.Methods Pathogenic bacteria isolated from blood culture in a hospital microbiology laboratory between January 2012 and December 2015 were collected and divided into 2012-2013 group and 2014-2015 group,distribution characteristics,constitute,and antimicrobial susceptibility of two groups were compared.Results Gram-negative bacteria were the main pathogens isolated during two periods,ac-counting for 54.96% and 54.66% respectively,there was no significant differences in pathogen distribution between two groups (P >0.05).Gram-positive cocci had a high sensitivity to vancomycin and linezolid,resistant rates were both 0;resistance rates of coagulase negative staphylococci to oxacillin were all >80%,resistance to penicillin was also >90%;Enterobacteriaceae was highly sensitive to imipenem and meropenem,but resistance strains had ap-peared;Acinetobacter baumannii was sensitive to minocycline during two periods,resistance rates were 35.90% and 34.55% respectively,resistance rates to other antimicrobial agents were also high (>75%).Conclusion The iso-lation rate of drug-resistant pathogenic strains causing bloodstream infection is high,monitoring on bacterial resistance is helpful for guiding rational use of antimicrobial agents in clinic.