Protective effect of the methanol extract of Polyopes lancifolia (Harvey) kawaguchi et wang against ionizing radiation-induced mouse gastrointestinal injury.
- Author:
Jinwoo JEONG
1
;
Wonjun YANG
;
Meejung AHN
;
Ki Cheon KIM
;
Jin Won HYUN
;
Sung Ho KIM
;
Changjong MOON
;
Taekyun SHIN
Author Information
1. Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju 690-756, Korea. shint@jejune.ac.kr
- Publication Type:Original Article
- Keywords:
antioxidation;
intestinal progenitor cells;
irradiation;
Polyopes lancifolia (Harvey) kawaguchi et wang;
red seaweed
- MeSH:
Animals;
Apoptosis;
Catalase;
Cats;
Liver;
Methanol;
Mice;
Oxidative Stress;
Rhodophyta;
Stem Cells;
Superoxide Dismutase
- From:Korean Journal of Veterinary Research
2011;51(3):177-183
- CountryRepublic of Korea
- Language:English
-
Abstract:
The radioprotective efficacy of a methanol extract of the red algae Polyopes lancifolia (Harvey) kawaguchi et wang (mPL) was evaluated in mice subjected to total-body gamma irradiation. mPL protection against radiation-induced oxidative stress was examined by histological evaluation of intestinal crypt-cell survival and liver activities of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT). mPL (100 mg/kg body weight) administered intraperitoneally at 24 h and 1 h prior to irradiation protected jejunal crypt cells from radiation-induced apoptosis (p < 0.01). The pretreatment of mPL attenuated a radiation-induced decrease in villous height (p < 0.05), and improved jejunal crypt survival (p < 0.05). The dose reduction factor was 1.14 at 3.5 days after irradiation. Treatment with mPL prior to irradiation resulted in significantly higher (p < 0.01) levels of SOD and CAT activities, compared to those levels of irradiated control mice with vehicle treatment. These results suggest that mPL is a useful radioprotective agent capable of defending intestinal progenitor cells against total-body irradiation, at least in part through mPL antioxidative activity.
