Investigution and Analysis of Off-label Drug Use in Fertility Clinic of One Hospital
- VernacularTitle:某院生殖中心门诊超说明书用药调查分析
- Author:
Wei CHEN
1
;
Jing HUANG
;
Xiquan YU
Author Information
1. 福州总医院药学科 福州350025
- Keywords:
Reproductive center;
Off-label drug use;
Standardized management;
Rational drug use
- From:
China Pharmacist
2017;20(10):1805-1808
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the situation of off-label drug use in fertility clinic of one hospital to provide scientific evidence for clinical rational drug use and further standardize the behavior of off-label drug use in clinical physicians. Methods:The outpatient prescriptions in the reproductive center of the hospital during January and December in 2016 were randomly selected, the off-label drug use prescriptions were statistically analyzed according to the drug package inserts, and the rationality of the off-label drug use were e-valuated by searching the related literatures. Results:A total of 4176 off-label drug use prescriptions were collected, the primary types of off-label drug use were off-label indication, off-label dose and off-label administration. The top 3 drugs with off-label use were aspi-rin enteric-coated tablets (42. 05%), dydrogesterone tablets (27. 37%) and levocarnitine oral solution (16. 02%). The most of off-label use was supported by evidence-based medicines, while unreasonable use still existed. Conclusion: Off-label drug use is very common in the reproductive center of the hospital. The hospital should pay more attention to the phenomenon and establish relevant management system to standardize the behavior of off-label drug use in order to reduce the legal risk and promote clinical rational drug use.
