Research Progress in Focal Adhesion Kinase Used for Neurological Diseases
- VernacularTitle:粘着斑激酶在神经系统疾病中的作用研究进展
- Author:
Xia LIAN
1
;
Xiaofeng LIN
;
Liqun ZHEN
;
Tingting YANG
;
Yan FEI
Author Information
1. 解放军第175医院药学科 福建漳州363000
- Keywords:
Focal adhesion kinase;
Integrin;
Neurological diseases;
Research progress
- From:
China Pharmacist
2017;20(10):1846-1849
- CountryChina
- Language:Chinese
-
Abstract:
Focal adhesion kinase ( FAK) is one of novel non-receptor protein tyrosine kinases critical for the dynamic regulation of cell adhesion structures,which is activated through the phosphorylation of its tyrosine residue by ligands that bind to integrins. Some studies have demonstrated that FAK has close relationship with nervous system development, synaptic plasticity and the occurrence and development of nervous system diseases. The review summarized the functions of FAK in neurological diseases.
