Abdominal and Pericardial Fat in Patients with and without Coronary Artery Disease: Computed Tomography Study.
- Author:
Gwan Hyeop SOHN
1
;
Dong Woon KIM
;
Sang Min KIM
;
Sang Yeub LEE
;
Jang Whan BAE
;
Kyung Kuk HWANG
;
Sung Mok KIM
;
Yeon Hyeon CHOE
;
Jung Euy PARK
Author Information
- Publication Type:Original Article
- Keywords: Pericardial adipose tissue; Abdominal visceral adipose tissue; Abdominal subcutaneous adipose tissue; Computed tomography; Coronary artery disease
- MeSH: Abdominal Fat; Adipose Tissue; Adiposity; Angiography; Calcium; Chest Pain; Coronary Artery Disease*; Coronary Vessels; Humans; Intra-Abdominal Fat; Subcutaneous Fat, Abdominal
- From:Journal of Lipid and Atherosclerosis 2014;3(1):29-37
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: There has been a limited investigation looking into the correlation between pericardial fat and abdominal fat with coronary artery disease (CAD) as measured by coronary computed tomographic angiography (CCTA). We proposed that the volume of pericardial fat is larger in patients with CAD than in patients without CAD, and sought to determine which abdominal adiposity index best correlated with pericardial fat volume. METHODS: Participants were examined using CCTA between October 2007 and January 2008. All participants had no previous history of CAD. Pericardial adipose tissue (PAT) volume, abdominal total adipose tissue volume, abdominal subcutaneous adipose tissue volume, and abdominal visceral adipose tissue (AVAT) volume were measured using CCTA. RESULTS: Fifty patients (26.5%) demonstrated CAD, and 139 patients did not demonstrate CAD by CCTA. PAT volume in patients with CAD was larger than that of patients without CAD (173.2+/-64.2 cm3 vs. 147.6+/-50.4 cm3, p<0.01). However, indices of abdominal adiposity were not significantly different between the two groups. Using multivariable analysis, independent predictors of CAD were PAT volume (odds ratio [OR] 1.01, 95% confidence interval [CI] 1.00-1.02, p=0.04), coronary artery calcium score (OR 1.01, 95% CI 1.00-1.01, p<0.01), and typical chest pain (OR 4.88, 95% CI 1.47-16.21, p=0.01). AVAT volume showed a linear correlation with PAT volume. CONCLUSION: PAT volume was an independent predictor of CAD as measured by CCTA. PAT volume was also well correlated with the AVAT volume among the indices of abdominal adiposity.
