Data Analysis of Therapeutic Drug Monitoring for Three New Pediatric Antiepileptic Drugs
- VernacularTitle:儿童三种新型抗癫痫药物血药浓度监测结果分析
- Author:
Wenyan JIANG
1
;
Hongjian LI
;
Tingting WANG
;
Yan SUN
;
Luhai YU
Author Information
1. 新疆自治区人民医院药学部 乌鲁木齐830001
- Keywords:
Therapeutic drug monitoring;
Levetiracetam;
Lamotrigine;
Oxcarbazepine;
Children
- From:
China Pharmacist
2017;20(10):1795-1798
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the situation of therapeutic drug monitoring ( TDM) for 3 new antiepileptic drugs including leve-tiracetam, lamotrigine and oxcarbazepine in our hospital to provide reference for the individualized drug treatment for the children with epilepsy. Methods:The basic information, dose and TDM data of levetiracetam, lamotrigine and oxcarbazepine of the children with ep-ilepsy during 2015 and 2016 were collected and statistically analyzed in our hospital. Results: Without obvious difference in mean dose, the average plasma concentrations of oxcarbazepine in 3-6-year-old,6-10-year-old and 10-18-year-old children were significantly higher than those in less than 3-year-old children(P<0. 05). The mean dose and the average plasma concentrations of lamotrigine in children at different ages had no statistical significance(P>0. 05). The average plasma concentration of levetiracetam in less than 3-year-old children was significantly higher than that in the other children (P<0. 05). The effective rate of clinical treatment within dif-ferent plasma concentration ranges had statistical significance(P<0. 05). Conclusion: There are inter-individual differences in the plasma concentrations of antiepileptic drugs among the children with epilepsy at different ages. So the plasma concentration of antiepi-leptic drugs should be monitored regularly in order to ensure the safety and effectiveness of medication for children.
