Clinical Study on Apatinib Combined with Tegafur, Gimeracil and Ateracil Capsules in the Second-line Treatment of Advanced Gastric Mucinous Adenocarcinoma
- VernacularTitle:阿帕替尼联合替吉奥二线治疗晚期胃黏液腺癌观察
- Author:
Wenhui ZHANG
1
;
Qinglong ZHANG
;
Yaqin TAN
;
Liping LIU
Author Information
1. 包头市肿瘤医院 内蒙古包头014030
- Keywords:
Apatinib;
Tegafur;
gimeracil and oteracil capsules(TS-1);
Second-line;
Advanced gastric mucinous adenocarcinoma
- From:
China Pharmacist
2017;20(10):1798-1800
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the efficacy and safety of targeted drug apatinib combined with tegafur, gimeracil and oteracil capsules (TS-1) in the second-line treatment of advanced gastric mucinous adenocarcinoma. Methods: Totally 48 patients with ad-vanced gastric mucinous adenocarcinoma treated with the second-line regimen were randomly divided into the control group and the treatment group with 24 ones in each. The control group received the chemotherapy of TS-1, and the treatment group received apatinib additionally. The adverse reactions and objective effects were observed. Results:The objective response rate (ORR) was 54. 1% and 33. 3% in the treatment and the control group, respectively. The disease control rate (DCR) was 83. 3% and 54. 2% in the treatment and the control group, respectively. There were significant differences on ORR and DCR in both groups(P<0. 05), while no statisti-cal difference was shown in the adverse reactions (P>0. 05) between the two groups. Conclusion:Apatinib combined with TS-1 ex-hibits evident short-term therapeutic effect on advanced gastric mucinous adenocarcinoma, and the adverse reactions can be tolerated.
