Efficacy of Dexmedetomidine at Different Doses in Catheter Ablation for Atrial Fibrillation
- VernacularTitle:不同剂量右美托咪定用于心房颤动经导管射频消融术中的疗效
- Author:
Wei FENG
1
;
Qi CHEN
Author Information
1. 上海交通大学医学院附属新华医院麻醉科 上海200092
- Keywords:
Dexmedetomidine;
Atrial fibrillation;
Catheter ablation;
Sedation;
Analgesia
- From:
China Pharmacist
2017;20(10):1801-1805
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy and safety of dexmedetomidine ( DEX) at different loading doses during atrial fi-brillation ( AF) ablation. Methods:A total of 63 patients with AF undergoing radiofrequency catheter ablation were randomized into three groups:high loading dose group (HDex group, 1. 0 μg·kg-1), low loading dose group (LDex group, 0. 5 μg·kg-1) and NS group (the same volume of saline), and all were with 10 min intravenous infusion. After the loading dose, HDex group and LDex group were maintained continuously at an identical dose of 0. 4 μg·kg-1 ·h-1 DEX till the end of operation. The three groups were given 1% lidocaine local anesthesia at the beginning of surgery, and all the patients were intravenously given fentanyl (1μg·kg-1 · h-1 ) during the operation. The systolic blood pressure ( SBP) , diastolic blood pressure ( DBP) , heart rate ( HR) and Ramsay score were recorded before the iv pump infusion (T0), after the loading dose (T1), at the beginning of operation (T2), 10 minutes after the beginning of radiofrequency ablation (T3) and 10 minutes after the end of radiofrequency ablation (T4) were recorded. The num-ber of assisted ventilation, procedure interruption to adjust the dosage of fentanyl because of intorlerant pain and the total operation time were recorded as well. Results:The Ramsay scores were higher and SBP, DBP and HR decreased more notably in HDex and LDex group at T1, T2, T3 and T4 when compared with those in NS group(P<0. 05). At T1, SBP, DBP and HR decreased more evidently in HDex group than in LDex group. Two cases of bradycardia and two cases of assisted ventilation occurred in HDex group, and two ca-ses of pain caused procedure interruption occurred in NS group. Conclusion: When combined with fentanyl, the loading dose of 0. 5μg/kg/10 min DEX can provide satisfactory sedation and analgesic effects during AF ablation with fewer adverse reactions.
