Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor
- VernacularTitle:#
- Author:
Durán M. GEMA
1
;
Benavidez E. TOMÁS
;
Contento M. ANA
;
Ríos ANGEL
;
García D. CARLOS
Author Information
1. #
- Keywords:
Graphene quantum dots;
One-step synthesis;
Fluorescence quenching;
Penicillamine;
Pharmaceutical preparations
- From:
Journal of Pharmaceutical Analysis
2017;7(5):324-331
- CountryChina
- Language:Chinese
-
Abstract:
A simple methodology was developed to quantify penicillamine (PA) in pharmaceutical samples, using the selective interaction of the drug with Cu-modified graphene quantum dots (Cu-GQDs). The proposed strategy combines the advantages of carbon dots (over other nanoparticles) with the high affinity of PA for the proposed Cu-GQDs, resulting in a significant and selective quenching effect. Under the optimum conditions for the interaction, a linear response (in the 0.10–7.50 μmol/L PA concentration range) was observed. The highly fluorescent GQDs used were synthesized using uric acid as single precursor and then characterized by high resolution transmission electron microscopy, Raman spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, fluorescence, and absorption spectroscopy. The proposed methodology could also be extended to other compounds, further expanding the applicability of GQDs.
