Clinical features and prognosis of prostate cancer with high-grade prostatic intraepithelial neoplasia.
10.4111/kju.2015.56.8.565
- Author:
Donghyun LEE
1
;
Chunwoo LEE
;
Taekmin KWON
;
Dalsan YOU
;
In Gab JEONG
;
Jun Hyuk HONG
;
Hanjong AHN
;
Choung Soo KIM
Author Information
1. Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. cskim@amc.seoul.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Prostatectomy;
Prostatic intraepithelial neoplasia;
Prostatic neoplasms
- MeSH:
Aged;
Humans;
Lymphatic Metastasis;
Male;
Middle Aged;
Neoplasm Grading;
Neoplasm Invasiveness;
Peripheral Nerves/pathology;
Prognosis;
Prostatectomy;
Prostatic Intraepithelial Neoplasia/*pathology/surgery;
Prostatic Neoplasms/*pathology/surgery;
Recurrence;
Retrospective Studies
- From:Korean Journal of Urology
2015;56(8):565-571
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To evaluate the clinical features and biochemical recurrence (BCR) in prostate cancer (PCa) with high-grade prostatic intraepithelial neoplasia (HGPIN). MATERIALS AND METHODS: We retrospectively analyzed the medical records of 893 patients who underwent a radical prostatectomy for PCa between 2011 and 2012 at Asan Medical Center; 752 of these patients who did not receive neoadjuvant or adjuvant therapy and were followed up for more than 1 year were included. The cohort was divided into two groups-patients with and without HGPIN-and their characteristics were compared. The Cox proportional hazards model was used to analyze factors affecting BCR. RESULTS: In total, 652 study patients (86.7%) had HGPIN. There were no significant differences in preoperative factors between the two groups, including age (p=0.369) and preoperative prostate-specific antigen concentration (p=0.234). Patients with HGPIN had a higher Gleason score (p=0.012), more frequent multiple tumor (p=0.013), and more perineural invasion (p=0.012), but no other postoperative pathologic characteristics were significantly different between the two groups. There were no significant differences in BCR (13.0% vs. 11.5%, p=0.665) and HGPIN was not associated with BCR (p=0.745). In multivariate analysis, only the T stage (p<0.001) was associated with BCR. CONCLUSIONS: PCa patients with HGPIN have a higher Gleason score, more frequent multiple tumors, and more perineural invasion than those without HGPIN. The presence of HGPIN is not an independent predictor of BCR.
