Current Understanding of Stem Cell and Secretome Therapies in Liver Diseases.
10.1007/s13770-017-0093-7
- Author:
Dongkyu KIM
1
;
Gun Sik CHO
;
Choongseong HAN
;
Dong Hyuk PARK
;
Hee Kyung PARK
;
Dong Hun WOO
;
Jong Hoon KIM
Author Information
1. Laboratory of Stem Cells, NEXEL Co., Ltd., 9th Floor, 21 Wangsan-ro, Dongdaemun-gu, Seoul 02580, Korea.
- Publication Type:Review
- Keywords:
Liver failure;
Liver regeneration;
Stem cell transplantation;
Secretome
- MeSH:
Bone Marrow Cells;
Cell- and Tissue-Based Therapy;
Hematopoietic Stem Cells;
Hepatocytes;
Humans;
Inflammation;
Liver Cirrhosis;
Liver Diseases*;
Liver Failure;
Liver Regeneration;
Liver Transplantation;
Liver*;
Macrophages;
Mesenchymal Stromal Cells;
Stem Cell Transplantation;
Stem Cells*;
Tissue Donors
- From:
Tissue Engineering and Regenerative Medicine
2017;14(6):653-665
- CountryRepublic of Korea
- Language:English
-
Abstract:
Liver failure is one of the main risks of death worldwide, and it originates from repetitive injuries and inflammations of liver tissues, which finally leads to the liver cirrhosis or cancer. Currently, liver transplantation is the only effective treatment for the liver diseases although it has a limitation due to donor scarcity. Alternatively, cell therapy to regenerate and reconstruct the damaged liver has been suggested to overcome the current limitation of liver disease cures. Several transplantable cell types could be utilized for recovering liver functions in injured liver, including bone marrow cells, mesenchymal stem cells, hematopoietic stem cells, macrophages, and stem cell-derived hepatocytes. Furthermore, paracrine effects of transplanted cells have been suggested as a new paradigm for liver disease cures, and this application would be a new strategy to cure liver failures. Therefore, here we reviewed the current status and challenges of therapy using stem cells for liver disease treatments.
