Characterization of Cytokines Present in Pediatric Recurrent Otitis Media with Effusion: Comparison of Allergy and Nonallergy.
- Author:
Chul Ho JANG
1
Author Information
1. Department of Otolaryngology, Wonkwang Medical School, Iksan, Korea. chul@wonnms.wonkwang.ac.kr
- Publication Type:Original Article
- Keywords:
Pediatric;
Recurrent;
OME;
Cytokine;
Allergy
- MeSH:
Animals;
Cytokines*;
Ear;
Ear, Middle;
Enzyme-Linked Immunosorbent Assay;
Humans;
Hypersensitivity*;
Inflammation;
Interleukin-2;
Interleukin-4;
Interleukin-6;
Necrosis;
Otitis Media with Effusion*;
Otitis Media*;
Otitis*;
Tumor Necrosis Factor-alpha
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2000;43(8):808-812
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Earlier studies documented the presence of several cytokines in middlle ear effusions (MEEs) of humans and experimental animals. Some of these studies reported association between cytokine levels and certain clinical factors. Rut studies on association between cytokine levels and allergy in MEE are very rare. To acertain the role of allergy in the pathogenesis of recurrent otitis media with effusion(ROME) through the characterization of cytokines. MATERIALS AND METHODS: MEE samples were collected from patients with allergy (20 ears) and without allergy (15 ears). They were assayed for interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6 (IL-6), and tumor necrosis factor-alpha(TNF-alpha) using sandwich enzyme linked immunosorbent assay. RESULTS: The levels of IL-4, IL-6 and TNF-alpha in the allergy group were statistically higher than in the nonallergy group. The level of IL-2 in the allergy group was slightly higher than in the nonallergy group, but the difference was not statistically significant. CONCLUSION: Elevation of Th2 driven cytokines and TNF-alpha in MEEs suggests that ROME may be a sign of allergic inflammation in the middle ear.
