Expression of Vascular Endothelial Growth Factor and Platelet-Derived Endothelial Cell Growth Factor in Head and Neck Squamous Cell Carcinoma and It's Relation to Angiogensis.
- Author:
Hee Suck CHOI
1
;
Young Bum KIM
;
Young Ho SONG
;
Nam Pyo HONG
;
Hwoe Young AHN
;
Youn Hwa KIM
Author Information
1. Department of Otolayrngology, College of Medicine, Kyung Hee University, Seoul, Korea. khuent@unitel.co.kr
- Publication Type:Original Article
- Keywords:
Vascular endothelial growth Factor;
Platelet derived endothelial cell growth factor;
Angiogenesis;
Head and neck squamous cell carcinoma
- MeSH:
Carcinoma, Squamous Cell*;
Head*;
Larynx;
Microvessels;
Neck*;
Neoplasm Metastasis;
Thymidine Phosphorylase*;
Vascular Endothelial Growth Factor A*
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2000;43(8):854-861
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Tumor angiogenesis is an essential process required for growth and metastasis in cancer. Vascular endothelial growth Factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF) are known to be angiogenetic factors. The objectives of this study were to measure the expression of VEGF, PD-ECGF and microvessel density (MVD) in head and neck squamous cell carcinoma (HNSCC) and compare them to normal larynx. We also evaluated relationships of VEGF, PD-ECGF and MVD to clinicopathologic findings in HNSCC. MATERIAL AND METHODS: The expression of VEGF, PD-ECGF and MVD were evaluated by immunohistochemical staining of 26 cases of HNSCC and 6 cases of normal larynx. RESULTS: The expressions of VEGF, PD-ECGF and MVD in HNSCC were significantly higher than in the normal control (p<0.05). MVD were significantly correlated with VEGF and PD-ECGF expressions in HNSCC (p<0.05). The VEGF, PD-ECGF expression and MVD correlated with many clinicopathologic findings in HNSCC. CONCLUSION: These results suggest that VEGF and PD-ECGF are involved in angiogenesis and are related to clinicopathologic findings of HNSCC. Furthermore, we propose that expressions of VEGF, PD-ECGF and MVD to be investigated more in the future as prognostic indicators of HNSCC.
