Synthesis of new Imidazoline derives by the ethylene diamine cyclization from nitril compounds
- Author:
Truong The Ky
- Publication Type:Journal Article
- Keywords:
Ethylene diamine cyclization
- MeSH:
Imidazolines;
Cyclization
- From:Journal Ho Chi Minh Medical
2005;9(4):247-252
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The imidazol and imidazoline derives have many advantages in therapy. For the synthesis of new imidazoline derives, the authors implemented the ethylene diamene cyclization from nitril compounds differently substituted. Then, a dehydrogenation of these imidazolines leaded to the imidazol derives. The last reaction consisted of the condensation of these imidazolines and imidazoles. The authors subjected their synthesized products to an ophthalmic protective evaluation (anti-oedema, secondary anti-hyperemia) on the experimental ocular irritancy models
