Neoadjuvant Chemotherapy and Radiotherapy for the Treatment of Hypopharyngeal Cancer.
- Author:
Soo Geun WANG
1
;
Byung Joo LEE
;
Eui Kyung GOH
;
Tae Won KIM
;
Jeong Hyug AHN
;
Joo Seop CHUNG
;
Dong Won KIM
;
Ji Ho NAM
Author Information
1. Department of Otolaryngology, College of Medicine, Pusan National University, Busan, Korea. voicelee@yahoo.co.kr
- Publication Type:Original Article
- Keywords:
Hypopharyngeal neoplasms;
Neoadjuvant therapy;
Radiotherapy;
Organ preservation
- MeSH:
Busan;
Drug Therapy*;
Humans;
Hypopharyngeal Neoplasms*;
Laryngectomy;
Larynx;
Medical Records;
Neoadjuvant Therapy;
Organ Preservation;
Prognosis;
Radiotherapy*;
Retrospective Studies;
Survival Rate
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2003;46(12):1058-1063
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Hypopharyngeal cancer is notorious for its poor prognosis and severe surgical morbidity with functional deficits. This study was conducted to compare the efficacy between the neoadjuvant chemotherapy followed by radiotherapy and surgery with postoperative radiotherapy in the treatment of hypophayngeal cancer. MATERIAL AND METHOD: Medical records of 64 patients, treated for hypopharyneal cancer at Pusan National University Hospital from March 1986 through May 2000, were retrospectively reviewed. Thirty-three patients were grouped into the chemotherapy and radiotherapy (CRTx) group, who received neoadjuvant chemotherapy and radiotherapy. Thirty-one patients were grouped into the operation and radiotherapy (ORTx) group, who received laryngectomy with or without reconstruction and postoperative radiotherapy. RESULTS: There was no significant difference of three years survival rate between CRTx group and ORTx group (p>0.05). Laryngeal preservation rate was 45% in CRTx group but 3% in ORTx group (p<0.05). CONCLUSION: Although this had not been a randomized study of chemotherapy followed by radiotherapy versus surgery plus postoperative radiotherapy, the survival rate of CRTx group appears to be as identical as ORTx group and more effective in the preservation of the larynx.
