Expression of beta-catenin and Adenomatous Polyposis Coli(APC) Protein in Squamous Cell Carcinoma of the Laryngeal Cancers.
- Author:
Hoon PARK
1
;
Hyo Jin KIM
;
Jin Gyo PARK
;
Dong Wook KIM
;
Byung Don LEE
;
Hyuck Soon CHANG
Author Information
1. Department of Otolaryngology, College of Medicine, Soonchunhyang University, Seoul, Korea. kdw1228@hosp.sch.ac.kr
- Publication Type:Original Article
- Keywords:
beta-catenin;
Adenomatous polyposis coli (APC) protein;
Laryngeal neoplasms
- MeSH:
beta Catenin*;
Carcinoma, Squamous Cell*;
Cell Membrane;
Cytoplasm;
Cytosol;
Genes, APC;
Laryngeal Neoplasms*;
Lymph Nodes;
Neoplasm Metastasis;
Signal Transduction
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2005;48(3):352-356
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: beta-catenin has an essential role in intercellular adhesion and signal transduction. The Adenomatous poliposis coli (APC) protein interacts with beta-catenin in a multi-protein complex to regulate the level of expression of beta-catenin. Mutations in beta-catenin or APC gene can lead to the accumulation of beta-catenin in the cytosol and the nucleus. This study was designed to investigate the expression of APC and beta-catenin in laryngeal cancer. SUBJECTS AND METHOD: Immunohistochemical methods were used to determine the beta-catenin and APC protein expression in 15 laryngeal cancers. Results were correlated with clinicopathological parameters. RESULTS: beta-catenin expression to the plasma membrane was reduced or absent in 11 of 15 cases (73%) of the laryngeal cancers. Cytoplasmic expression of the beta-catenin was seen in 6 out of 15 cases (40%). APC immunoactivity was negative in 5 of 15 (33%) of the laryngeal cancers. One of the six cytoplasmic expressions of the beta-catenin was negative for APC immunoactivity, and one of the five negative for APC immunoactivity was cytoplasmic expression of the beta-catenin. CONCLUSION: There was no correlation between beta-catenin and APC protein in the analysis. This finding suggests that cytoplasmic expression of the beta-catenin resulted not from the APC mutation but from the beta-catenin mutation and abnormal Wnt signal. Only the expression of the beta-catenin in cytoplasm was associated with lymph node metastasis.
