Porous Beta-Calcium Pyrophosphate as a Bone Graft Substitute in a Canine Bone Defect Model.
10.4055/jkoa.2003.38.4.384
- Author:
Jae Hyup LEE
1
;
Dong Ho LEE
;
Jeong Hyun HA
;
Young Joon AHN
;
Jae Young PARK
;
Hyun Seung RYU
;
Bong Soon CHANG
;
Kug Sun HONG
;
Choon Ki LEE
Author Information
1. Department of Orthopedic Surgery, Seoul National University College of Medicine, Seoul, Korea. choonki@plaza.snu.ac.kr
- Publication Type:Original Article
- Keywords:
Bone defect;
Beta-calcium pyrophosphate;
Hydroxyapatite;
Bone graft substitute;
Resorbability
- MeSH:
Animals;
Bone Development;
Bone Regeneration;
Dogs;
Durapatite;
Radiography;
Tibia;
Transplants*
- From:The Journal of the Korean Orthopaedic Association
2003;38(4):384-392
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the possibility of using porous beta-calcium pyrophosphate (beta-CPP) as a bone graft substitute by comparing its osteoconduction and degradation with porous hydroxyapatite (HA). MATERIALS AND METHODS: Porous HA and porous beta-CPP were implanted in the proximal tibia of 7 dogs. Two animals were sacrificed at 8weeks and 5 animals were sacrificed at 20 weeks after surgery. Radiographs and histologic sections were evaluated. RESULTS: The mean period required for the radiolucent zone to disappear was 7.1+/-1.1 weeks in HA and 6.4+/-1.1 weeks in beta-CPP. By serial radiography, resorption was more prominent in porous beta-CPP than in porous HA at 8 weeks (p=0.04) and at 20 weeks. The proportion of bony tissue in the pore was 16.8% in HA and 29.7% in -CPP. The proportion of pores with bony tissue was 70.2% in HA and 62.5% in beta-CPP at 8 weeks. CONCLUSION: In beta-CPP, the new bone growth was as vigorous as in HA, but the degradation was more rapid than in HA. These results suggest that beta-CPP is a more ideal new bone graft substitute.
