Biological effects of blood–brain barrier disruption using a focused ultrasound.
10.1007/s13534-017-0025-4
- Author:
Mun HAN
1
;
Yongki HUR
;
Jieun HWANG
;
Juyoung PARK
Author Information
1. Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, 80 Cheombok-ro, Dong-gu, Daegu 41061, Republic of Korea. jyp@dgmif.re.kr
- Publication Type:Review
- Keywords:
Focused ultrasound;
Blood–brain barrier;
Microbubble;
Biological effects
- MeSH:
Alzheimer Disease;
Brain;
Microbubbles;
Neurogenesis;
Neurons;
Ultrasonography*
- From:
Biomedical Engineering Letters
2017;7(2):115-120
- CountryRepublic of Korea
- Language:English
-
Abstract:
With focused ultrasound (FUS) and microbubbles, BBB can be transiently disrupted with a localized and non-invasive approach. BBB disruption induced by FUS has made progressions to move forward on delivery of therapeutic agents into a brain in a specific area of brain for better treatment of neurological diseases. In addition to be used as an improvement of drug delivery, BBB disruption has been found to induce biological effects such as a clearance of protein aggregation which cause Alzheimer's disease, regulation of proteins which facilitate drug uptake, and modulation of neuronal function and neurogenesis. In this review, we discuss overview about the principles of BBB opening with FUS and milestones in these biological effects of FUS-induced BBB disruption.
