Effects of Verapamil on the Hemodynamic Responses to Nitroglycerin during Halothane-N2O Anesthesia.
- Author:
Song Soo NAH
1
;
Chan Jin PARK
;
Sung Su CHUNG
Author Information
- Publication Type:Original Article
- Keywords: Verapamil; Nitroglycerime; Hemodynamic responses
- MeSH: Anesthesia*; Arterial Pressure; Capillaries; Heart; Hemodynamics*; Humans; Hypotension; Nitroglycerin*; Stroke Volume; Verapamil*
- From:Korean Journal of Anesthesiology 1988;21(1):1-10
- CountryRepublic of Korea
- Language:Korean
- Abstract: Hemodynamic variables in 8 verapamil pretreated patients(the verapamil pretreated group) were compared with those in 10 patients without pretreatment(the control group) during nitroglycerin(NTG) induced hypotension under halothane-N2O anesthesis. The results were as follows: 1) In the control group, there were statistically significant decreases in mean arterial pressure (MAP)(25%), pulmonary arterial pressure(PAP)(32%), pulmonary capillary wedge pressure(PCWP)(30%), central venous pressure(CVP)(33%), but the heart rate(HR), cardiac output(CO), cardiac index(CI) and stroke volume index(SVI) remained unchanged. After discontinuance of NTG, all parameters returned to baseline levels. 2) Verapamil alone produced a small decrease in MAP(6%) and CVP(9%), but other hemodynamic values did not change. 3) In the verapamil pretreated group, there were significant decreases in MAP(23%), PAP(30%), PCWP(27%), CVP(20%), SVR(24%) and PVR(31%), but HR, CO, CI, and SVI remained unchanged. 4) These results indicated that verapamil did not significantly affect the hemodynamic response to NTG under halothane-N2O Anesthesis.
