Biomechanical Analysis of the Effect of Pamidronate on Prevention of Osteoporosis in Ovariectomized Rats.
- Author:
Ki Hyun CHO
1
;
Seong Seok SEO
;
Jang Seok CHOI
Author Information
1. Department of Orthopaedic Surgery, Pusan Paik Hospital, Inje University, Pusan, Korea.
- Publication Type:Original Article
- Keywords:
Osteoporosis;
Pamidronate;
Biomechanical analysis
- MeSH:
Animals;
Estrogens;
Extremities;
Female;
Femur;
Mice;
Osteoporosis*;
Ovariectomy;
Rats*;
Rats, Sprague-Dawley;
Spine;
Tibia
- From:The Journal of the Korean Orthopaedic Association
2000;35(6):837-844
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study intended to examine the effect of pamidronate, when it was administrated in early estrogen deficiency period, by examining biomechanically bone mass generated in trunkal and extremity bone with bone strength examination. MATERIALS AND METHODS: 17-weeks-old 95 mice of Sprague-Dawley lines were divided into 1st group 28mice, 2nd group 25mice and 3rd group 42mice. The 1st group was sham-operated group, 2nd group underwent bilateral ovariectomy and then injected intravenously normal saline 0.05cc, and 3rd group underwent bilateral ovariectomy and then injected intravenously pamidronate 0.1mg/Kg. RESULTS: The strength of femur, tibia and spine was surveyed with Young' modulus. Femur and spine had a statistically significant difference between 1 and 2 group, 2 and 3 group, and tibia had between 2 and 3 group. CONCLUSION: In early osteoporosis, pamidronate administration is supposed to prevent or decrease osteoporosis and fracture resulting from osteoporosis.
