Inhibition of the Cardiovascular Response to Tracheal Intubation by Low - dose Fentanyl.
10.4097/kjae.1988.21.1.39
- Author:
Choon Kun CHUNG
1
Author Information
1. Department of Anesthesiology, Inha Hospital, Kyonggi-Do, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Intubation-tracheal;
Analgesics-fentanyl
- MeSH:
Adult;
Anesthesia;
Fentanyl*;
Heart;
Hemodynamics;
Humans;
Hypertension;
Intubation*;
Respiratory Insufficiency;
Thiopental
- From:Korean Journal of Anesthesiology
1988;21(1):39-43
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The hemodynamic response evoked by tracheal intubation was observed in 20 adult normotensive patients undergoing elective surgery. Patients were randomly assigned to receive either thiopental 6 mg/kg(n=10) or fentanyl 6ug/kg with thiopental 3mg/kg(n=10), for induction of anesthesia. Systolic blood pressure(SBP), diastolic blood pressure(DBP), mean arterial pressure(MAP) and heart rate(HR) were measured at 1 min., 3 min. and 5 min. after intubation. In the thiopental group, intubation caused a significant rise in SBP, DBP, MAP, HR(p<0.05) but each parameter returned to normal within 5 min. In the fentanyl thiopental group intubation caused little cardiovascular change, but within 5 minutes MAP decreased significantly from 101 mmHg to 83 mmHg(p<0.05). It is concluded that a low-dose of fentanyl which may cause minimal postoperative respiratory depression, significantly prevents postintubation hypertension when used as an adjunct to thiopental for the induction of anesthesia.
