Patterning of Ventral Neural Tube in Tg737(oprk) Mutant.
- Author:
Sae Ock OH
1
;
Soo Kyung BAE
;
Sik YOON
;
Sun Yong BAEK
;
Bong Seon KIM
;
Jae Bong KIM
Author Information
1. Department of Anatomy, College of Medicine, Pusan National University, Korea. kimjb@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
Tg737 Polaris;
Cilia;
Ventral neural tube;
Shh
- MeSH:
Animals;
Cilia;
Hedgehogs;
Interneurons;
Mice;
Motor Neurons;
Neural Tube*
- From:Korean Journal of Anatomy
2005;38(1):73-81
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Polaris, which is encoded by Tg737 gene, has been associated with cilia formation. Recently pheno-types of ventral neural tube in mice who have abnormal cilia formation have been reported to be similar with those of sonic hedgehog (Shh)signaling mutants. These interesting findings lead us to further examine the patterning of ventral neural tube in Tg737(oprk) mice. In this study, we found that motor neuron and V2 interneuron were preserved whereas P3 progenitor domain and floor plate were missing in Tg737(oprk) mutant. V2 and motor neurons in Tg737(oprk) were ventralized and ixed with each other. Nkx6.1 and Olig2 expressions were preserved and the Olig2 expression was ventralized in Tg737(oprk). These penotypes are quite similar with those in Shh(-/-); Gli3(-/-) or Gli2(-/-) ; Gli3(-/-) mutants, suggesting that the function of Polaris might be involved in Shh signaling.
