Antioxidative and Antidiarrheal Effects of Persimmon Extracts.
10.5625/lar.2010.26.4.407
- Author:
Dongsun PARK
1
;
Sun Hee LEE
;
Dae Kwon BAE
;
Young Jin CHO
;
Tea Kyun KIM
;
Yun Hui YANG
;
Goeun YANG
;
Sang Chul KWON
;
Do Ik LEE
;
Sung Soo JOO
;
Yun Bae KIM
Author Information
1. College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea. solar9@cbu.ac.kr
- Publication Type:In Vitro ; Original Article
- Keywords:
Persimmon;
antioxidative activity;
antidiarrheal activity;
gastrointestinal motility
- MeSH:
Ascorbic Acid;
Biphenyl Compounds;
Diarrhea;
Diospyros;
Gastroenteritis;
Gastrointestinal Motility;
Lipid Peroxidation;
Oxidative Stress;
Picrates
- From:Laboratory Animal Research
2010;26(4):407-413
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Since oxidative stresses are involved in gastroenteritis and diarrhea, we investigated antioxidative and antidiarrheal activities of persimmon flesh extract (PFE) and persimmon calyx extract (PCE) in vitro and in vivo, respectively. PCE significantly scavenged 1,1-diphenyl-2-picrylhydrazyl hydrate and 2,2'-azinobis (3-ethylbenzthiazoline-6-sulfonic acid) from 500 microg/mL, although PFE was ineffective. In addition, PFE and PCE exhibited strong nitric oxide-scavenging effects from 1 microg/mL, in which PCE was superior to ascorbic acid (50 microM). Furthermore, PFE and PCE significantly inhibited FeCl3-induced lipid peroxidation as well as Cu2+/H2O2-induced protein oxidation from 10 microg/mL. In vivo charcoal-propulsion assay, in contrast to a negligible effect of PFE, treatment with PCE (160-500 mg/kg) markedly inhibited intestinal motility. The results indicate that extracts of persimmon, especially PCE, possess antioxidative, antiinflammatory and antidiarrheal activities. Therefore, it is suggested that persimmon extracts could be used for the relief of gastroenteritis and diarrhea.
