Endothelial Progenitor Cells' Classification and Application in Neurological Diseases.
10.1007/s13770-017-0043-4
- Author:
Jing jing YUAN
1
;
Jing YANG
;
Shi lei SUN
;
Rui ZHANG
;
Yu ming XU
Author Information
1. Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, 1 Jian-she East Road, Zhengzhou 450000, Henan, China. ruizhangyy@126.com, 13903711125@126.com
- Publication Type:Review
- Keywords:
Early endothelial progenitor cells;
Endothelial outgrowth cells;
Cell origin;
Surface antigen expression;
Neurological disease
- MeSH:
Classification*;
Endothelial Progenitor Cells;
Stroke;
Therapeutic Uses
- From:
Tissue Engineering and Regenerative Medicine
2017;14(4):327-332
- CountryRepublic of Korea
- Language:English
-
Abstract:
The therapeutic effects of endothelial progenitor cells (EPCs) on ischemic stroke have been extensively studied in recent years. However, the differences in early EPCs and endothelial outgrowth cells (EOCs) are still unclear. Clarifications of their respective properties and specific functioning characteristics contribute to better applications of EPCs in ischemic diseases. In this review, we discuss cellular origin, isolation, culture, surface markers of early EPCs and EOCs and relevant applications in neurological diseases. We conclude that EOCs possess all haracteristics of true endothelial progenitors and have potent advantages in EPC-based therapies for ischemic diseases. A number of preclinical and clinical applications of EPCs in neurological diseases are under study. More studies are needed to determine the specific characteristics of EPCs and the relevant mechanisms of EPCs for neurological diseases.
