Effects of medicinal herb water extracts on expression of hepatic glucokinase, pyruvate dehydrogenase and acetyl-CoA carboxylase mRNA.
10.4163/kjn.2013.46.2.119
- Author:
Hyun Sook KIM
1
;
Tae Woo KIM
;
Dae Jung KIM
;
Jae Sung LEE
;
Myeon CHOE
Author Information
1. Well-being Bioproducts RIC Center, Kangwon National University, Chuncheon 200-701, Korea. mchoe@kangwon.ac.kr
- Publication Type:Original Article
- Keywords:
anti-diabetic;
glucokinase;
pyruvate dehydrogenase;
acetyl-CoA carboxylase;
medicinal herb
- MeSH:
Acetyl Coenzyme A;
Acetyl-CoA Carboxylase;
Cornus;
Glucokinase;
Lycium;
Oxidoreductases;
Paeonia;
Plants, Medicinal;
Pyrus;
Pyruvic Acid;
Rehmannia;
RNA, Messenger;
Water
- From:The Korean Journal of Nutrition
2013;46(2):119-125
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We studied the anti-diabetic effects of medicinal herb water extracts on expression of hepatic glucokinase (GCK), pyruvate dehydrogenase (PDH), and acetyl-CoA carboxylase (ACC) mRNA. The medicinal herbs used for experiments were Cornus officinalis (CO), Paeonia suffruticosa Andrews (PSA), Discorea japonica Thunb. (DJ), Rehmannia glutinosa (RG), Lycium chinense (LC), and Pyrus pyrifolia (PP). For GCK mRNA expression, CO, RG, and LC water extracts exhibited a more effective activity than other extracts. Cells treated with RG and LC water extracts showed an increase in expression of PDH mRNA to 191% and 124%, respectively, compared to control. Expression of ACC mRNA was significantly higher in LC water extract. These data indicate that CO, RG, and LC water extracts stimulates expression of hepatic GCK, PDH, and ACC mRNA.
