Effect of Young Barley Leaf on Lipid Contents and Hepatic Lipid-Regulating Enzyme Activities in Mice Fed High-Fat Diet.
- Author:
Eun Ju YANG
1
;
Young Sook CHO
;
Myung Sook CHOI
;
Myoung Nam WOO
;
Myung Joo KIM
;
Mi Yae SHON
;
Mi Kyung LEE
Author Information
1. Department of Nutrition Education, Graduate School of Education, Sunchon National University, Suncheon 540-742, Korea.
- Publication Type:Original Article
- Keywords:
young barley leaf;
body weight;
lipid content;
lipid metabolism
- MeSH:
Acyl Coenzyme A;
Adipose Tissue;
Animals;
Body Weight;
Cholesterol;
Diet;
Diet, High-Fat;
Eating;
Energy Intake;
Fatty Acid Synthetase Complex;
Heart;
Hordeum;
Humans;
Kidney;
Lipid Metabolism;
Liver;
Male;
Mice;
Oxidoreductases;
Plasma;
Sterol O-Acyltransferase;
Water
- From:The Korean Journal of Nutrition
2009;42(1):14-22
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study was conducted to investigate the effects of powdered young barley leaf and its water extract on body weight and lipid metabolism in high-fat fed mice. Male mice were divided into normal group, high-fat (HF) group, highfat group supplemented with powdered young barley leaf (HF-YBL) and high-fat group supplemented with water extract of the powdered young barley leaf (HF-WYBL). The powdered young barley leaf or its water extract was added to a standard diet based on 1% dried young barley leaf (1 g YBL/100 diet and 0.28 g WYBL/100 g diet) for 8 weeks. Supplementation of YBL and WYBL significantly reduced body weight and epididymal adipose tissue weight in highfat fed mice. Food intake and daily energy intake were significantly lower in the YBL group than in the HF group. After 8 weeks, plasma triglyceride and cholesterol concentrations were significantly higher in the HF group than in the Normal group; however, both YBL and WYBL significantly lowered those of the high-fat fed mice. The ratio of HDL-cholesterol/ total cholesterol of the YBL and WYBL groups were significantly elevated compared to that of HF group. Both YBL and WYBL significantly increased fecal excretion of triglyceride in high-fat fed mice, whereas they did not affect fecal cholesterol concentration. The triglyceride levels of liver, adipose tissue and heart were significantly lower in the YBL and WYBL groups than in the HF group. Supplementation of WYBL also lowered the kidney triglyceride and heart cholesterol concentrations compared to those of HF group. Hepatic lipid regulating enzyme activities, fatty acid synthase, HMG-CoA reductase and acyl-coenzyme A: cholesterol acyltransferase, were significantly lower in the YBL and WYBL groups than in the HF group. Accordingly, these results suggest that YBL and WYBL improve plasma and organ lipid levels partly by increasing fecal lipid excretion and inhibiting fatty acid and cholesterol biosynthesis in the liver.
